Cystatin C: Analysis and Utility in Monitoring GFR

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Does adjustment of GFR to extracellular fluid volume improve the clinical utility of cystatin C?

BACKGROUND Cystatin C measurement has been proposed as a replacement for creatinine as a serum measure of glomerular filtration rate (GFR). It has also been suggested that GFR itself should be adjusted to the extracellular fluid volume (ECV) of a child rather than the body surface area (BSA). AIMS To assess the potential of cystatin C compared to serum creatinine in assessing GFR and to estab...

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Cystatin C versus creatinine-based GFR formula in CKD patients

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Estimated GFR and risk of death--is cystatin C useful?

Current estimates suggest that as many as one in six persons in North America have chronic kidney disease,1 a condition that may worsen over time and signal the need for continuous monitoring. Knowing which patient with chronic kidney disease is at risk for end-stage kidney disease or death could tell us who needs intensive monitoring or intervention. The glomerular filtration rate (GFR), the c...

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Analytical study of three cystatin C assays and their impact on cystatin C-based GFR-prediction equations.

BACKGROUND Cystatin C-based equations are used to estimate GFR. However, three cystatin C immunoassays are on the market. Difference in cystatin C assays could have strong consequences on the accuracy and precision of cystatin C-based equations. We have performed an analytical study of these three assays and studied potential differences between assays on the precision of cystatin C-based equat...

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S-cystatin C formulae or combination of s-cystatin C and s-creatinine formulae do not improve prediction of GFR.

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ژورنال

عنوان ژورنال: Laboratory Medicine

سال: 2003

ISSN: 0007-5027,1943-7730

DOI: 10.1309/p3bchuj4jb0hdrc2